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Dutasteride and tamsulosin hydrochloride capsules are used to treat the symptoms of benign prostatic hyperplasia (BPH) in men with an enlarged prostate.
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The complementary mechanisms affect hormonal and smooth muscle pathways, respectively, to inhibit enlargement of the prostate and produce muscular relaxation to decrease symptoms.
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Thus far, almost every study has shown that when done by experienced urologists, the laser enlarged prostate surgery produces results that are equal to those with TURP, but without the severe side effects and risks.
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Endpoints included changes in prostate volume, peak urinary flow rate, risk of surgical intervention, safety and tolerability, and measurements of serum PSA, testosterone, and DHT.
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Testosterone treatment improves body composition and sexual function in men with COPD, in a 6-month randomized controlled trial.
Additionally, the MTOPS trial used the type-2 5α-reductase inhibitor finasteride whereas the CombAT study assesses the results of treatment using the dual 5α-reductase inhibitor dutasteride.
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Similar to the case during Merck's Finasteride testing back in the 1990s, Avodart's helpful effects on hair loss got to be obvious during GlaxoSmithKline's clinical trials of the medication as a treatment for BPH.
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The European Prospective Investigation into Cancer and Nutrition examined the association between fruit and vegetable intake and subsequent prostate cancer.
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Sometimes the two types of drugs are used in combination.
Finasteride has proven to selectively inhibit the Type 2 isoenzyme whereas dutasteride competitively inhibits both forms of the enzyme.
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